Nigeria approves two GMO cotton Varieties

Nigeria ratifies two genetically modified heterogeneity of cotton.  The strains were modified by the Institute of Agricultural Research at the Ahmadu Bello University in the northern city of Zaria in collaboration with privately owned Mayco Nigeria Ltd. to include a gene that makes it pest resistant, according to Rose Gidado, assistant director at the Abuja-based National…

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“Naroban5” pest, disease resistant bananas

“Naroban5” crops were launch at the ministry’s department of crop inspection and certification office at Namalere Kawanda, in Wakiso district. A banana breeder with the National Agricultural Research Organization (NARO), said Naroban5 tastes and looks as good as traditional heterogeneity. Dr. Rabooni Tumuhimbise noted that the banana type is resistant to key banana diseases and…

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Version of CRISPR/Cas3 more impactful gene-editing tool

Investigators at Cornell University (Ithaca, NY, USA) delineate that Cas3 from Thermobifida fusca was found to be guided specifically towards Cascade-bound target DNA in the presence of an optimal Protospacer Adjacent Motif (PAM) sequence, and through physical interplay with the CasA component of the Cascade and the non-complementary strand of the ds-DNA substrate. This means…

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Anti-Cancer treatment targets activated platelets in tumor microenvironment

A novel chemotherapeutic agent transport system is based on the binding of an antibody-drug conjugate specifically directed to an exterior protein on energizing platelets in the tumor microenvironment. Based on the premise that platelets in the blood are progressively conceding as mediators of tumor swelling and metastasis, investigators at the Baker Heart and Diabetes Institute…

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Genome editing used to bias genetic inheritance in mice

Genomics researchers have demonstrated the feasibility of using CRISPR/Cas9 gene editing to bias genetic inheritance in mice used for laboratory studies. Investigators at the University of California, San Diego (USA) based their work in mice on the highly efficient gene drive systems that have recently been developed in insects. These systems leveraged the sequence-targeted DNA…

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Novel DNA vaccine prevents AD in mouse model

In the current study, the investigator used a triple-transgenic mouse model that grows plaques and tangles in the brain similar to human AD. Four cohorts of between 15 and 24 mice each were injected in the skin with DNA coding for the Abeta42 peptide. The researchers had already shown that full-length DNA Abeta42 trimer immunization was non-inflammatory and…

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Subpopulation of fibroblasts drives breast tumor development

Cancer-associated fibroblasts are especially prominent in breast tumors, but the nature of their function and origin not been uncertain completely. Consequently, recruitment of BM-derived CAFs to primary tumors and metastases resulted in a gradual reduction in PDGFR alpha levels, which was apparently also in human breast tumors, and correlated with worse outcome. The finding that…

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Mechanism explains why damaged DNA amass in ALS neurons

A mechanism that leads to the accumulation of damaged DNA in neurons that characterize amyotrophic lateral sclerosis (ALS). A team of neurodegenerative disease researchers recognizes. ALS is a neurodegenerative disease signalized by the selective and progressive death of upper and lower motor neurons. This leads to ongoing muscle weakness, and death of the patient usually…

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Eradicate liver protein enhance glucose metabolism

Researchers working with a mouse model have determined that the Argonaute 2 (Ago2) protein intervene RNA silencing, which regulates both intrinsic energy production and consumption and disturbs energy metabolism in the development of obesity. Argonaute proteins are the catalytic element of the RNA-induced silencing complex (RISC), the protein complex responsible for RNA interference (RNAi) gene…

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