Eradicate liver protein enhance glucose metabolism

Researchers working with a mouse model have determined that the Argonaute 2 (Ago2) protein intervene RNA silencing, which regulates both intrinsic energy production and consumption and disturbs energy metabolism in the development of obesity. Argonaute proteins are the catalytic element of the RNA-induced silencing complex (RISC), the protein complex responsible for RNA interference (RNAi) gene…

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Novel approach brings personalized melanoma treatment closer to reality

A team of melanoma researchers used a novel “HLA peptidomics” method to discover and isolate cancer-specific neo-antigens, which could be used to train immune system cells for targeting and destruction of the tumor. The quest for tumor-associated-antigens (TAAs) and neo-antigens is a vital focus of cancer immunotherapy. Neo-antigens are those that are entirely absent from…

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Sanctioned drugs effectively suppress extension of lethal pathogen

Some currently approved drugs were found to suppress the growth of the amoeba Naegleria fowleri by inhibiting enzymes in the organism’s sterol biosynthesis pathway. Naegleria fowleri is a free-living amoeba found mainly in warm, under-chlorinated swimming pools, lakes, and rivers that can also act as an opportunistic pathogen causing the critical brain infection, primary amebic…

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FAO Surveys New Plant Breeding Approach in Iran

An evolutionary, participatory plant breeding approach compatible with the Iranian environment has been victorious in decline vulnerabilities of small-scale farmers, raise crop yields and boosting crop flexibility to drought and other stressful events. The above outcome was declared in the 2018 report on the State of Food Security and Nutrition in the World published by…

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Polysome screen discover Cancer allied MicroRNAs

An international research team has evolve a polysome-based technique for detecting microRNAs (miRNAs) that act to encourage or sustain growth of acrimonious mesothelioma and other types of cancer. MicroRNAs are short RNA molecules about 22 nucleotides in length. Essentially, miRNAs specifically target obvious messenger RNAs (mRNAs) to prevent them from coding for a distinct protein….

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Blocking glucose metabolism prevents development of metabolic syndrome

A novel approach to preventing diabetes and other expression of metabolic syndrome, which includes obesity, diabetes, and fatty liver disease, showed promising results in mouse model systems. The response by the liver to fasting has been present as a therapeutic pathway to boost hepatic and whole-host metabolism. However, the mechanisms underlying these metabolic consequences remain…

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