ARID1A Mutations Linked to ATR Anti-Cancer Drug Sensitivity

A team of British cancer researchers suggested in a recent paper that screening for mutations in the ARID1A (AT-rich interactive domain-containing protein 1A) gene could aid in identifying patients with tumors sensitive to the ATR inhibitor class of anti-cancer drugs. Mutations in ARID1A represent one of the most common molecular alterations in human cancer especially…

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Antioxidant In Green Tea Reverses Arthritis Symptoms in Rat Model

Recently investigators at Washington State University (Spokane, USA) worked with cultures of IL-1beta (interleukin 1beta)–stimulated human RA synovial fibroblasts (RASFs) as well as with a rat model of adjuvant-induced arthritis (AIA). They revealed that the green tea compound epigallocatechin-3-gallate (EGCG) was shown to effectively reverse the symptoms of adjuvant-induced arthritis (AIA) in a rat model,…

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Experiment Shows UV Damage and Skin Cancer Can Be Prevented From Annatto Component

Investigators at the University of Arizona (Tucson, USA) based their research on recent studies that suggested a photoprotective role of gene expression in skin cells orchestrated by the transcription factor Nrf2 (nuclear factor-E2-related factor 2). They explored the molecular mechanism underlying carotenoid-based systemic skin photoprotection in the SKH-1 mouse model. A group of SKH-1 mice…

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Leishmaniasis can be treated with Selective Ribosome-Targeting Drug with Low Ototoxicity

In the new study, a team of researchers, led by Timor Baasov, professor at the Technion – Israel Institute of Technology (Haifa, Israel), investigated the structural basis for the targeting of leishmanial ribosomes by AGs and performed comparative testing of the potential clinical effectiveness and side-effects of new (semi-) synthetic derivatives of aminoglycoside paromomycin (PAR). In…

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Developmental Biologists Locate Source of Liver Stem Cells

The investigators at Stanford University (Palo Alto, CA, USA) reported in the August 5, 2015, online edition of the journal Nature  that they had identified a population of proliferating and self-renewing cells adjacent to the central vein in the liver lobule that is responsible for the generation of liver cells (hepatocytes). Working with mice, investigators traced the…

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Chimeric Drug Reduces Local Inflammation Without Causing General Immune Suppression

Investigators at Ben-Gurion University of the Negev (Beer Sheba, Israel) and the University of Colorado (Boulder, USA) created the chimeric drug by fusing the N-terminal peptide of interleukin-1beta (IL-1beta) to IL-1R antagonist (IL-1Ra), resulting in inactive IL-1Ra. Results published in the July 8, 2015, online edition of Journal of Immunology revealed that chimeric IL-1Ra reduced IL-1–mediated…

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