Novel DNA vaccine prevents AD in mouse model

In the current study, the investigator used a triple-transgenic mouse model that grows plaques and tangles in the brain similar to human AD. Four cohorts of between 15 and 24 mice each were injected in the skin with DNA coding for the Abeta42 peptide. The researchers had already shown that full-length DNA Abeta42 trimer immunization was non-inflammatory and…

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Subpopulation of fibroblasts drives breast tumor development

Cancer-associated fibroblasts are especially prominent in breast tumors, but the nature of their function and origin not been uncertain completely. Consequently, recruitment of BM-derived CAFs to primary tumors and metastases resulted in a gradual reduction in PDGFR alpha levels, which was apparently also in human breast tumors, and correlated with worse outcome. The finding that…

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Mechanism explains why damaged DNA amass in ALS neurons

A mechanism that leads to the accumulation of damaged DNA in neurons that characterize amyotrophic lateral sclerosis (ALS). A team of neurodegenerative disease researchers recognizes. ALS is a neurodegenerative disease signalized by the selective and progressive death of upper and lower motor neurons. This leads to ongoing muscle weakness, and death of the patient usually…

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Eradicate liver protein enhance glucose metabolism

Researchers working with a mouse model have determined that the Argonaute 2 (Ago2) protein intervene RNA silencing, which regulates both intrinsic energy production and consumption and disturbs energy metabolism in the development of obesity. Argonaute proteins are the catalytic element of the RNA-induced silencing complex (RISC), the protein complex responsible for RNA interference (RNAi) gene…

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Novel approach brings personalized melanoma treatment closer to reality

A team of melanoma researchers used a novel “HLA peptidomics” method to discover and isolate cancer-specific neo-antigens, which could be used to train immune system cells for targeting and destruction of the tumor. The quest for tumor-associated-antigens (TAAs) and neo-antigens is a vital focus of cancer immunotherapy. Neo-antigens are those that are entirely absent from…

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Sanctioned drugs effectively suppress extension of lethal pathogen

Some currently approved drugs were found to suppress the growth of the amoeba Naegleria fowleri by inhibiting enzymes in the organism’s sterol biosynthesis pathway. Naegleria fowleri is a free-living amoeba found mainly in warm, under-chlorinated swimming pools, lakes, and rivers that can also act as an opportunistic pathogen causing the critical brain infection, primary amebic…

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FAO Surveys New Plant Breeding Approach in Iran

An evolutionary, participatory plant breeding approach compatible with the Iranian environment has been victorious in decline vulnerabilities of small-scale farmers, raise crop yields and boosting crop flexibility to drought and other stressful events. The above outcome was declared in the 2018 report on the State of Food Security and Nutrition in the World published by…

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