Conditions in the tumor microenvironment change role of p53

Earlier studies have revealed that in contrast to the situation in CAFs, p53 in normal fibroblasts (NFs) plays a tumor-suppressive role to restrict tumor growth. Cancer researchers have found that changes happen in the tumor microenvironment manipulate the activity of fibroblast p53 protein, causing it to boost rather than restrict cancer growth. This transcriptional rewiring…

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Gel encapsulation transport system targets disease-related cells

A novel therapeutic approach uses drugs encapsulated within galacto‐oligosaccharide gel capsules to attack diseases that have assembled a high percentage of senescent cells. Senescent cells are aged or harm cells that no longer are able to perform their normal roles. In a model of chemotherapy‐induced senescence, gal‐encapsulated cytotoxic drugs targeted senescent tumor cells and upgrades…

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Stem cell- establish cultures used for brain disease research

A team of neurological disease researchers used stem cell technology to culture mini-organoids comprising all the major cell types found in the human cerebral cortex – including oligodendrocytes – for brain structure/function research. Oligodendrocytes make myelin, the fatty substance that wraps supports, and insulates nerve cells and connections. Nerve cells that lack myelin cannot convey…

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Plants can appraise the time using sugars

A new study by an international team of scientists, including Dr. Antony Dodd of the University of Bristol’s School of Biological Sciences, has discovered that plants calibrate their daily circadian rhythm to the cycle of day and night by measuring the volume of sugars in their cells. Plants, animals, fungi and some bacteria can estimate…

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Chinese experts to train 40 Pakistani scientists in modern agriculture techniques

Chinese Government had signed a memorandum of understanding for capacity building of local scientists in field of modern agriculture techniques and increases the yield of hybrid rice.In first phase a batch of 40 scientists nominated from all over the country would be edifying to promote and develop the hybrid rice production technology in the country,…

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Mitochondrial DNA depletion linked to depletion syndromes

Physiological slump due to depletion of mitochondrial DNA, such as markers of aging like wrinkled skin and hair loss, was shown to be reversed by repair of normal mitochondrial DNA levels and function. Mitochondrial DNA (mtDNA) depletion is involved in mtDNA depletion syndromes, mitochondrial diseases, aging and aging-associated chronic diseases and other human pathologies such…

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Synthetic fatty acid derivatives present anti-cancer capability

Metabolites fabricate during digestion of omega-3 fatty acids have been found to have anti-cancer properties, and their synthetic derivatives have the potential to be developed into potent chemotherapeutic drugs. Dietary omega-3 fatty acids, such as docosahexaenoic acid (DHA), have been shown to suppress tumor thickening across their conversion to epoxide metabolites. Alternatively, DHA is transformed…

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Novel bacterial inhibitor blocks lysozyme activity in model

A team of molecular microbiologists has identified a mechanism by which certain bacteria specifically gram-negative pathogen Neisseria gonorrhoeae – avoid lysozyme demolition. Lysozyme, also known as muramidase or N-acetylmuramide glycanhydrolase is an antimicrobial enzyme prefabricated by animals that form part of the intrinsic immune system. Lysozymes are omnipresent as the first line of immune patronage…

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Genetic code growth used to evince biological control mechanism

A team of genomics researchers has expressed the development of a novel biological switching mechanism that authorizes control over the activity of the CRISPR/Cas9 gene-editing tool. CRISPR/Cas9 is considered as the cutting edge of molecular biology technology. Several applications of genome editing by CRISPR-Cas9 necessitate rigid regulation and Cas9 modification have been appropriately generated whose…

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MicroRNA biomarker recognize for bladder cancers

Cancer researchers have identified a microRNA that acts as a prognostic biomarker of p53-like bladder cancers. Cancer researchers have identified a microRNA that acts as a prognostic biomarker of p53-like bladder cancers. MicroRNAs (miRNAs) and short interfering RNAs (siRNA) comprise a class of about 20 nucleotides-long RNA fragments that block gene expression by attaching to…

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