Institutional Achievements
H. E. J. Research Institute of Chemistry (H. E. J. R. I. C), University of Karachi, Karachi. |
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| Medicine |
Discovery of Plant materials with pronounced anti-diabetic, anti-epileptic and cholesterol lowering activities. Many of the structurally novel compounds isolated were found to have interesting pharmacological profiles and are in different stages of efficacy trials. Discovery of new inhibitors of clinically important enzymes, which can be used to stop the disease processes involve in the enzyme-related disorders. As a result several new classes of lead molecules were made known to the world of Science along with associated understanding of their mechanism of action. Discovery of a large number of fascinating molecules with potential therapeutic applications. |
| Transgenic Plant Technology |
Commercial production of ornamental plants using tissue culture technology. Mass scale production of pineapple plants using tissue culture technology. Mass multiplication of virus and disease free banana and orchids plants using tissue culture technology. The use of DNA fingerprinting to evaluate the genetic stability of banana plants produced via in-vitro culture. Establishment of model hydroponics culture systems for the cultivation of Pineapples and some other important cut flowers. Establishment of Tissue Culture Technology Park in the University of Karachi . Establishment of Medicinal Plant Collection and Processing Facility at Khanuspur. Establishment of research and development facilities for exotic cut flower and value added products. Application of the Biotransformation techniques to produce value added compounds using plant cell cultures. Isolation of structurally novel and pharmacologically potent compounds from plant cell suspension cultures. Development of economical protocols for the pilot scale production of elite date palm cultivars using plant tissue culture technology. |
Center For Molecular Genetics (CMG), University of Karachi, Karachi. |
Development of lab-scale environmental biological filters technology for treating industrial effluent (the technology is now being up-scaled to pilot level with a generous financial grant from the Government of Pakistan). The discovery of pcoABCDRSE genes (submission of gene sequence to gene-bank pending) for resistance to copper in a bacterium Enterobacter sp. CMG457. The co-discovery of czrSRCBA genes (gene sequence submitted to the gene-bank: EMBL under accession № Y14018) in a bacterium Pseudomonas aeruginosa CMG103 that are involved in resistance mechanism against cadmium and zinc. The discovery of a bacterium Pseudomonas aeruginosa CMG607W that produces polyhydroxy alkanoates (PHA) which can be used to manufacture the environment friendly biodegradable plastics. The phaABC1ZC2D genes (responsible for PHA production) have also been identified in this microorganism (submission of gene sequence to gene-bank pending). Its strong presence in the field of environmental bioremediation is highlighted by the thoroughness of its research programme which includes development of eco-friendly biological control measures for agricultural pests as an alternative to the conventional chemical insecticides and pesticides. The centre has also discovered bacteria that promote plant growth by making metals bound tightly to soil particles available in water-soluble form to the plants; such metals are usually needed by plants as essential trace elements.
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Center of Excellence in Molecular Biology (CEMB), University of Punjab, Lahore. |
TRANSGENIC PLANT TECHNOLOGY |
ENVIRONMENTAL BIOTECHNOLOGY |
HEALTH & MEDICAL DIAGNOSTICS |
Basic Research |
PRODUCTION ACTIVITIES |
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2 ENZYME PRODUCTIONS |
INSTITUTE OF AGRICULTURAL BIOTECHNOLOGY AND NARC, Islamabad |
RESEARCH ACHIEVEMENTS |
Commercialization of the technology for quality seed potato production has resulted in visible decline in seed imports from approximately 5,000 tons in the early 1980s to less than 1,000 tonnes in the 1990s. This has brought savings to the tune of Rs.130 million annually In date palm all stages from lab to land till the fruit bearing at the farmers' field have been successfully demonstrated. Replacement of date palm shoots produced through tissue culture could boost the exports from 27 million US$ to 1 billion US $ annually. In banana, in vitro protocols for "cavendish" or "basrai" are developed. This important activity was taken up because of the loss of banana crop due to the Banana Bunchy Top Virus (BBTV) which caused an annual loss of Rs. 1 billion to the farmers. In genetic engineering, scientists have developed a "binary vector" for Xa21 gene which was transformed into agrobacterium strains EHA101 setting the stage for transgenic plant production in basmati rice through agrobacterium mediated formation. Within 2-3 years this transgenic line would become available to the farmers. This technology is cost effective in developing countries like Pakistan . |
NATIONAL INSTITUTE FOR BIOTECHNOLOGY AND GENETIC ENGINEERING, (NIBGE) Faisalabad |
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COMMERCIAL ACTIVITIES IN TISSUE CULTURE |
Virus Free Seed Potato Production Through Biotechnology
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Biomedical & Genetic Engineering Division, Dr. A. Q. Khan Research Laboratories, Islamabad. |
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Institute of Biotechnology and Genetics Engineering, (IBGE) NWFP Agriculture University , Peshawar |
Genetic improvement of Brassica oilseed by integrative use of conventional and molecular biological approaches. |
Ayub Agriculture Research Institute, (AARI) Faisalabad. |
Development of genetically high yielding better quality varieties of wheat, cotton, Maize, fruits, rice, pulses, fodders, oilseeds, sugarcane, vegetables, etc. concurrent pyramiding genes for tolerance against a biotic and biotic stresses and adaptability to wide range of environmental conditions. Development of crop production technology and its dissemination to the farmers through extension departments, electronic and print media. Production of pre-basic and basic seed in close association of Punjab Seed Corporation and its distribution to the farmers. Establishment of critical limits for essential plant nutrient elements, nutrient dynamics and their indexation. Reclamation of salt affected soils and use of tube-well water, soil, plant and fertilizer testing, identification of salt tolerant crop varieties and production package in problematic soils. To develop cost effective sustainable technology for the control of soil erosion and moisture conservation. Exploration of the feasibility of exploitation of industrial wastes in agriculture to check environmental pollution. Field and laboratory evaluation of new fertilizer and soil amendment Improvement of soil fertility and crop yields through microbial inoculants (bio-fertilizer) for sustainable agriculture. Determination of quality aspects of crops, level and effect on environmental pollution and utilization of Agro-industrial wastes in animal feeds. Quality testing of pesticides Crop residue management for sustaining the soil productivity Development of post-harvest technology of fruits and vegetables Research and Development work on the processing and preservation of fruits and vegetables. Extension of technical guidance to the entrepreneurs, farmers and females regarding processing and preservation of different foods and food products. Pilot scale production of different food products in order to popularize their quality, economics and processed foods among the masses Genetic improvements of crop varieties are the major objective of AARI. "It have developed 292 new varieties among which 56 wheat, 11 rice, and 34 cotton varieties. Potato seed prepared through tissue culture at AARI is of high quality and is supplied to the whole country. Development of high yielding disease free sugarcane varieties through tissue culture. |
Nuclear Institute for Agriculture Biology (NIAB) Faisalabad. |
Sustainable utilization of wasteland and saline groundwater. Tree water use Efficient N fertilizer for salt-affected lands. Water use efficiency of field crops. Soil Physics & Hydrological Studies. |
